Bristol-Myers Squibb
Senior Principal Scientist - Protein Structure Prediction and Design, Predictive
Bristol-Myers Squibb, Redwood City, California, us, 94064
Working with UsChallenging.
Experience, qualification, and soft skills, have you got everything required to succeed in this opportunity Find out below.
Meaningful.
Life-changing.
Those aren’t words that are usually associated with a job.
But working at Bristol Myers Squibb is anything but usual.
Here, uniquely interesting work happens every day, in every department.
From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.
You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity.
Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment.
We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Read more: careers.bms.com/working-with-us.When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit.
IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS.
We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company.
We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines.
In doing so, our work transforms the lives of patients, as well as our own lives and careers.Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.
You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.JOB DESCRIPTION We are seeking an experienced, creative, and collaborative scientist with expertise in protein structure prediction and physics-based modeling.
You will be responsible for the research and development of innovative computational approaches and workflows to predict, design, and characterize structural models that can help us develop novel biologics.
This role provides the opportunity to leverage large-scale proprietary datasets and work with subject matter experts on cross-functional teams to solve challenging problems in how we discover and engineer the next generation of biotherapeutics. We are deeply passionate about what we do here at Bristol Myers Squibb because we know that our work helps deliver truly innovative and life-changing therapies for complex diseases of unmet medical need.
If this inspires you as well, we’re excited to have you join us! RESPONSIBILITIES Pioneer machine learning research into antibody-antigen interaction modeling and design using internal and external datasets. Partner with project teams to advance sequence- and structure-based antibody discovery and design.
Develop and implement computational approaches and prediction algorithms that can map linear and three-dimensional epitopes, optimize binding scaffolds and library design to guide screening, predict and mature the affinity of antibody hits, and assess potential liabilities and optimal development options.
Communicate findings and recommend follow-up actions in multiple settings such as 1:1, seminars, group, and project meetings. BASIC QUALIFICATIONS:Bachelor's Degree in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and 10+ years of academic / industry experienceor Master's Degree in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and 8+ years of relevant experienceor PhD in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and
6+ years of academic / industry experiencePREFERRED QUALIFICATIONSPh.D in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program with 6+ years of relevant experience. Deep expertise in modern neural network architectures including transformers, autoencoders, CNNs, equivariant GNNs, and diffusion models.
Familiarity with PyTorch and its ecosystem, as well as other platforms such as scikit-learn, and design of effective experiments and metrics. Experience with deep learning structure prediction programs like AlphaFold2, physics-based modelling and protein docking packages like Rosetta, and state-of-the-art machine learning approaches for protein sequence data. Proven track record of contributing to and helping advance multi-disciplinary team projects.
Expertise with a high-level programming language such as R or Python for sophisticated data analysis and reproducible research practices. Scientific curiosity with an ability to identify questions machine learning approaches can address, and the skills to develop solutions both independently and collaboratively. Excellent problem-solving skills and teamwork. Strong communication, data presentation, and visualization skills. Knowledge in biochemistry or protein engineering is a plus. The starting compensation for this job is a range from $159,000 to $185,000 plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location.
For more on benefits, please visit our BMS Career Site.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care.
Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
Financial well-being resources and a 401(K).
Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Parental, caregiver, bereavement, and military leave.
Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
Other perks like tuition reimbursement and a recognition program.#QLRIf you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway.
You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as “Transforming patients’ lives through science ”, every BMS employee plays an integral role in work that goes far beyond ordinary.
Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles.
Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer.
If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com.
Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities.
As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Experience, qualification, and soft skills, have you got everything required to succeed in this opportunity Find out below.
Meaningful.
Life-changing.
Those aren’t words that are usually associated with a job.
But working at Bristol Myers Squibb is anything but usual.
Here, uniquely interesting work happens every day, in every department.
From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.
You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity.
Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment.
We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Read more: careers.bms.com/working-with-us.When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit.
IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS.
We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company.
We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines.
In doing so, our work transforms the lives of patients, as well as our own lives and careers.Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.
You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.JOB DESCRIPTION We are seeking an experienced, creative, and collaborative scientist with expertise in protein structure prediction and physics-based modeling.
You will be responsible for the research and development of innovative computational approaches and workflows to predict, design, and characterize structural models that can help us develop novel biologics.
This role provides the opportunity to leverage large-scale proprietary datasets and work with subject matter experts on cross-functional teams to solve challenging problems in how we discover and engineer the next generation of biotherapeutics. We are deeply passionate about what we do here at Bristol Myers Squibb because we know that our work helps deliver truly innovative and life-changing therapies for complex diseases of unmet medical need.
If this inspires you as well, we’re excited to have you join us! RESPONSIBILITIES Pioneer machine learning research into antibody-antigen interaction modeling and design using internal and external datasets. Partner with project teams to advance sequence- and structure-based antibody discovery and design.
Develop and implement computational approaches and prediction algorithms that can map linear and three-dimensional epitopes, optimize binding scaffolds and library design to guide screening, predict and mature the affinity of antibody hits, and assess potential liabilities and optimal development options.
Communicate findings and recommend follow-up actions in multiple settings such as 1:1, seminars, group, and project meetings. BASIC QUALIFICATIONS:Bachelor's Degree in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and 10+ years of academic / industry experienceor Master's Degree in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and 8+ years of relevant experienceor PhD in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program and
6+ years of academic / industry experiencePREFERRED QUALIFICATIONSPh.D in structural bioinformatics, computational biology, computer science, engineering, physics, or a similar program with 6+ years of relevant experience. Deep expertise in modern neural network architectures including transformers, autoencoders, CNNs, equivariant GNNs, and diffusion models.
Familiarity with PyTorch and its ecosystem, as well as other platforms such as scikit-learn, and design of effective experiments and metrics. Experience with deep learning structure prediction programs like AlphaFold2, physics-based modelling and protein docking packages like Rosetta, and state-of-the-art machine learning approaches for protein sequence data. Proven track record of contributing to and helping advance multi-disciplinary team projects.
Expertise with a high-level programming language such as R or Python for sophisticated data analysis and reproducible research practices. Scientific curiosity with an ability to identify questions machine learning approaches can address, and the skills to develop solutions both independently and collaboratively. Excellent problem-solving skills and teamwork. Strong communication, data presentation, and visualization skills. Knowledge in biochemistry or protein engineering is a plus. The starting compensation for this job is a range from $159,000 to $185,000 plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location.
For more on benefits, please visit our BMS Career Site.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care.
Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
Financial well-being resources and a 401(K).
Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Parental, caregiver, bereavement, and military leave.
Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
Other perks like tuition reimbursement and a recognition program.#QLRIf you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway.
You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as “Transforming patients’ lives through science ”, every BMS employee plays an integral role in work that goes far beyond ordinary.
Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles.
Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer.
If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com.
Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities.
As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.