Principal Scientist, Computer-Aided Drug Design (CADD) - La Jolla, California

Job Description - Principal Scientist, Computer-Aided Drug Design (CADD) – La Jolla, California (2506230924W)

Johnson & Johnson Innovative Medicine (JJIM) is recruiting for a Principal Scientist, Computer-Aided Drug Design (CADD, Computational Chemistry), to join our In Silico Drug Discovery team located in San Diego, California (La Jolla area).

Key Responsibilities Include:

• Design therapeutic molecules and calculate their properties using state-of-the-art methodologies integrating chemical, biological and structural data, cheminformatics, and artificial intelligence/machine learning techniques.
• Serve as a scientific expert in multi-disciplinary discovery project teams that include synthetic chemists, structural biologists, and other discovery scientists, by providing key expertise in the use and interpretation of data related to drug targets and their ligands.
• Collaborate within Janssen and with external academic and industrial partners to develop new computational technologies to address key questions in drug discovery.
• Publish results in peer-reviewed journals and present at scientific meetings.
• Mentor junior scientists, fostering their development as expert computational drug hunters.

Qualifications:

• A PhD in computational chemistry or a related field, with at least 2 years of experience applying computational modeling in a pharmaceutical industry drug design setting is required.
• Familiarity with at least one standard computational drug discovery package (examples may include, Maestro/Schrodinger, MOE/Chemical Computing Group, and/or OpenEye tools) is required.
• Experience with one or more of: working in a cross-functional environment, mentoring scientists, influencing decisions and resolving conflicts is strongly preferred.
• Experience with multiple therapeutic modalities (e.g. small molecules, biologics, peptides, targeted protein degraders) is preferred.
• Experience scripting computational workflows in Pipeline Pilot, Knime, Python or Jupyter notebooks is preferred.
• Excellent written and verbal communication skills, and a strong publication record is required.
• This position is located in La Jolla, CA and requires up to 10% travel domestically and internationally.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.