Senior Scientist (RNASeq Library Prep, Single-cell genomics, spatial transcripto

The highly successful Laboratory for Inflammatory Skin Diseases at the Kimberly and Eric J. Waldman Department of Dermatology at Icahn School of Medicine at Mount Sinai, which is responsible for exciting discoveries leading to the development of new treatments, is seeking a highly motivated Senior PhD-Level Scientist to join our expanding lab. The ideal candidate should possess a deep understanding of NGS and Single Cell technologies, with proven experience in efficiently managing large sample volumes with precision. They should be expert at troubleshooting and interpreting results from molecular and cellular assays. Comfort in a dynamic, academic, and entrepreneurial environment is essential. This role is ideal for individuals who enjoy working within a structured team setting rather than pursuing an independent research track as a principal investigator. 

The candidate will be responsible for the laboratory's genomics (NGS, Single Cell, and Special transcriptomics) and proteomics (OLINK proteomics) aspects, ensuring timely completion of research projects and training and supervising assigned Research Associates.

This is a full-time on-site wet lab role. As a key team member, you will contribute to the NGS, Single Cell, and Special Transcriptomics studies underlying new treatments for Inflammatory Skin Disorders. You will be responsible for running and troubleshooting scientific experiments, working in a cohesive cross-functional setting, and supporting a team environment.

This is a wet lab position. Please do not apply if you are looking for a bioinformatics/data analysis position.

Responsibilities

• Reviews and implements laboratory state of the art procedures for NGS, single cell and spatial transcriptomics.
• Assists in generating and collecting data.
• Evaluates new sample analysis techniques or methodology.
• Interprets experimental data.
• Provides education and training to lab members on equipment, techniques, etc.
• Execute and implement complex lab protocols to characterize skin and blood samples.
• Execute assay and reagent troubleshooting, optimization, validation of experiments, and appropriate documentation to support procedures and protocols, including data capture, forms, logbooks, and inventory batch records.
• On-boarding and development of new assays and troubleshooting where required
• Keep detailed records of work and testing
• Supervise method and instrument qualification and validation.
• Summarize methods for publications and assist with publications for scientific journals.
• Effectively plan and ensure project deliverables and timelines are met.

Qualifications

• PhD plus three years of postdoctoral or industrial hands-on lab work experience in NGS, Single Cell, and/or Spatial transcriptomics (absolute must have great experience (at least 3 years) in NGS and single cell).
• Experience must be documented through notable authorship in peer-reviewed publications or equivalent industrial exposure (required).
• Experience with platforms including Illumina, 10X Chromium, Vizgen-MERSCOPE or 10X Visium/Xenium, or Nanostring GeoMx.
• Ability to work independently and collaboratively in a team environment (required)
• Effective communication skills (required) and ability to document and present research findings.
• Willingness to learn, adapt, and support a cohesive team environment
• Excellent attention to detail and ability to follow protocols accurately
• Strong analytical and problem-solving skills
• A minimum 2-year commitment is required.